Art And Science In Beautiful Conversation!

Science Fact Friday: Tetrodotoxin, ft. a small gif because I’m avoiding my real obligations. Why does tetrodotoxin not affect its host? More studies need to be done but at least a few species possess mutated sodium ion channels. The tetrodotoxin can’t interact efficiently with the altered channels.

Another interesting tidbit: Animals with tetrodotoxin can lose their toxicity in captivity. It is suspected that the animals accumulate the toxic bacteria as a side-effect of their diet. After several years of captivity on a tetrodotoxin-bacteria-free diet, the bacterial colonies living in the animals die, residual toxin is cleared from the system, and the animal is safe to handle.

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(Image caption: An fMRI scan shows regions of the brain that become active when devoutly religious study participants have a spiritual experience, including a reward center in the brain, the nucleus accumbens. Credit: Jeffrey Anderson)

This is your brain on God

Religious and spiritual experiences activate the brain reward circuits in much the same way as love, sex, gambling, drugs and music, report researchers at the University of Utah School of Medicine. The findings were published in the journal Social Neuroscience.

“We’re just beginning to understand how the brain participates in experiences that believers interpret as spiritual, divine or transcendent,” says senior author and neuroradiologist Jeff Anderson. “In the last few years, brain imaging technologies have matured in ways that are letting us approach questions that have been around for millennia.”

Specifically, the investigators set out to determine which brain networks are involved in representing spiritual feelings in one group, devout Mormons, by creating an environment that triggered participants to “feel the Spirit.” Identifying this feeling of peace and closeness with God in oneself and others is a critically important part of Mormons’ lives — they make decisions based on these feelings; treat them as confirmation of doctrinal principles; and view them as a primary means of communication with the divine.

During fMRI scans, 19 young-adult church members — including seven females and 12 males — performed four tasks in response to content meant to evoke spiritual feelings. The hour-long exam included six minutes of rest; six minutes of audiovisual control (a video detailing their church’s membership statistics); eight minutes of quotations by Mormon and world religious leaders; eight minutes of reading familiar passages from the Book of Mormon; 12 minutes of audiovisual stimuli (church-produced video of family and Biblical scenes, and other religiously evocative content); and another eight minutes of quotations.

During the initial quotations portion of the exam, participants — each a former full-time missionary — were shown a series of quotes, each followed by the question “Are you feeling the spirit?” Participants responded with answers ranging from “not feeling” to “very strongly feeling.”

Researchers collected detailed assessments of the feelings of participants, who, almost universally, reported experiencing the kinds of feelings typical of an intense worship service. They described feelings of peace and physical sensations of warmth. Many were in tears by the end of the scan. In one experiment, participants pushed a button when they felt a peak spiritual feeling while watching church-produced stimuli.

“When our study participants were instructed to think about a savior, about being with their families for eternity, about their heavenly rewards, their brains and bodies physically responded,” says lead author Michael Ferguson, who carried out the study as a bioengineering graduate student at the University of Utah.

Based on fMRI scans, the researchers found that powerful spiritual feelings were reproducibly associated with activation in the nucleus accumbens, a critical brain region for processing reward. Peak activity occurred about 1-3 seconds before participants pushed the button and was replicated in each of the four tasks. As participants were experiencing peak feelings, their hearts beat faster and their breathing deepened.

In addition to the brain’s reward circuits, the researchers found that spiritual feelings were associated with the medial prefrontal cortex, which is a complex brain region that is activated by tasks involving valuation, judgment and moral reasoning. Spiritual feelings also activated brain regions associated with focused attention.

“Religious experience is perhaps the most influential part of how people make decisions that affect all of us, for good and for ill. Understanding what happens in the brain to contribute to those decisions is really important,” says Anderson, noting that we don’t yet know if believers of other religions would respond the same way. Work by others suggests that the brain responds quite differently to meditative and contemplative practices characteristic of some eastern religions, but so far little is known about the neuroscience of western spiritual practices.

The study is the first initiative of the Religious Brain Project, launched by a group of University of Utah researchers in 2014, which aims to understand how the brain operates in people with deep spiritual and religious beliefs.

Trillion-Ton Iceberg Breaks Off Antarctica

Even though the towering berg weighs more than 1.1 trillion tons (1 trillion metric tons), it won't have a direct impact on sea-level rise. That's because the ice was already floating on the sea. Even so, when an iceberg like this one calves, it can speed up the collapse of the rest of the ice shelf.

One of the largest icebergs ever recorded, packing about a trillion tons of ice or enough to fill up two Lake Eries, has just split off from Antarctica, in a much anticipated, though not celebrated, calving event.

A section of the Larsen C ice shelf with an area of 2,240 square miles (5,800 square kilometers) finally broke away some time between July 10 and today (July 12), scientists with the U.K.-based MIDAS Project, an Antarctic research group, reported today.

Continue Reading.

Dive deep into Episode 05 of #ShelfLife to discover the various technologies that have helped humans map the sky around us for eons. 

From sundials to mega-powered modern telescopes, tools for stargazing allow us to understand the universe—and our place within it. Season 2 begins on November 1. 

Why we need GMOs to survive climate change

Genetically modified organisms get a bad rap for many reasons, but we’ve actually been genetically altering what we eat since the dawn of human history.

“For 10,000 years, we have altered the genetic makeup of our crops,”explains UC Davis plant pathology professor Pamela Ronald.

“Today virtually everything we eat is produced from seeds that we have genetically altered in one way or another.” (You can read more about Ronald’s thoughts on genetically engineered food here.)

Right now her focus is on rice. It’s one of our basic crops and without it, we would struggle to feed much of the world.

With climate change, we’re seeing an increase in flooding in places like India and Bangladesh, which makes it harder to grow this important food staple.

So Ronald and her lab have developed a flood-tolerant strain of rice. It’s known as Sub1a or “scuba rice” and millions of farmers in South Asia are now growing it in their fields. 

Today is National Food Day, a day dedicated to hunger awareness. But as we focus on food insecurity, we need to talk more about how global warming will make the problem worse.

As our climate continues to heat up, it has huge impacts on what foods we are able to grow. Will our crops be able to survive droughts and floods? The University of California leads six labs that are working to develop other climate-resilient crops including chickpea, cowpea and millet.

Find out what other scientists are doing to improve our food.

Superconducting Bismuth Is Real, and It's Forcing Us to Rethink the Nature of Superconductivity

A Nobel Prize-winning theory has been challenged.

Bismuth is one of the weirdest-looking elements on the Periodic Table, but its internal properties just got even stranger. Scientists have discovered that at a fraction of a degree above absolute zero (-273.15°C), bismuth becomes a superconductor - a material that can conduct electricity without resistance.

According to the current theory of superconductivity, that doesn’t make a whole lot of sense, because for 40 years now, scientists have assumed that superconducting materials must be abundant in free-flowing mobile electrons. But in bismuth, there’s just one mobile electron for every 100,000 atoms.

“In general, compounds that exhibit superconductivity have roughly one mobile electron per atom,” Srinivasan Ramakrishnan from the Tata Institute of Fundamental Research in India explained to Chemistry World.

“However, in bismuth, one mobile electron is shared by 100,000 atoms – since [the] carrier density is so small, people did not believe bismuth will superconduct.”

Continue Reading.

Are colour-changing octopuses really colourblind? 

Cephalopods, including octopuses and squid, have some of the most incredible colour-changing abilities in nature. 

They can almost instantly blend in with their surroundings to evade predators or lay in wait, and put on colourful displays to attract mates or dazzle potential prey.

This is impressive enough on its own, but becomes even more amazing when you discover these creatures are in fact colourblind – they only have one type of light receptor in their eyes, meaning they can only see in black and white.

So how do they know what colours to change to at all?

This has puzzled biologists for decades but a father/son team of scientists from the University of California, Berkeley, and Harvard University think the unusual shape of their pupils holds the key, and they can see colour after all.

Cephalopods have wide U-shaped or dumbbell-shaped pupils, which allow light into the lens from many directions.

When light enters the pupils in human eyes it gets focused on one spot, cutting down on blur from the light being split into its constituent colours.

The scientists believe cephalopod eyes work the opposite way – the wide pupils split the light up and then individual colours can be focused on the retina by changing the depth of the eyeball and moving the pupil around.  

The price for this is blurry vision, but it does mean they could make out colours in a unique way to any other animals.

Processing colour this way is more computationally intensive than other types of colour vision and likely requires a lot of brainpower, which might explain in part why cephalopods are the most intelligent invertebrates on Earth.

Read the paper

Images:  Roy Caldwell, Klaus Stiefel, Alexander Stubbs

8 of the world’s most bizarre flowers:

1.) Swaddled Babies

2.) Flying Duck Orchid

3.) Hooker’s Lips Orchid

4.) Ballerina Orchid

5.) Monkey Orchid

6.) Naked Man Orchid

7.) Laughing Bumblebee Orchid

8.) White Egret Orchid

Using the Power of Space to Fight Cancer

From cancer research to DNA sequencing, the International Space Space is proving to be an ideal platform for medical research. But new techniques in fighting cancer are not confined to research on the space station. Increasingly, artificial intelligence is helping to “read” large datasets. And for the past 15 years, these big data techniques pioneered by our Jet Propulsion Laboratory have been revolutionizing biomedical research.

Microgravity Research on Space Station

On Earth, scientists have devised several laboratory methods to mimic normal cellular behavior, but none of them work exactly the way the body does. Beginning more than 40 years ago aboard Skylab and continuing today aboard the space station, we and our partners have conducted research in the microgravity of space.  In this environment, in vitro cells arrange themselves into three-dimensional groupings, or aggregates. These aggregates more closely resemble what actually occurs in the human body. Cells in microgravity also tend to clump together more easily, and they experience reduced fluid shear stress – a type of turbulence that can affect their behavior. The development of 3D structure and enhanced cell differentiation seen in microgravity may help scientists study cell behavior and cancer development in models that behave more like tissues in the human body.

In addition, using the distinctive microgravity environment aboard the station, researchers are making further advancements in cancer therapy. The process of microencapsulation was investigated aboard the space station in an effort to improve the Earth-based technology. Microencapsulation is a technique that creates tiny, liquid-filled, biodegradable micro-balloons that can serve as delivery systems for various compounds, including specific combinations of concentrated anti-tumor drugs. For decades, scientists and clinicians have looked for the best ways to deliver these micro-balloons, or microcapsules, directly to specific treatment sites within a cancer patient, a process that has the potential to revolutionize cancer treatment.

A team of scientists at Johnson Space Center used the station as a tool to advance an Earth-based microencapsulation system, known as the Microencapsulation Electrostatic Processing System-II (MEPS-II), as a way to make more effective microcapsules. The team leveraged fluid behavior in microgravity to develop a new technique for making these microcapsules that would be more effective on Earth. In space, microgravity brought together two liquids incapable of mixing on Earth (80 percent water and 20 percent oil) in such a way that spontaneously caused liquid-filled microcapsules to form as spherical, tiny, liquid-filled bubbles surrounded by a thin, semipermeable, outer membrane. After studying these microcapsules on Earth, the team was able to develop a system to make more of the space-like microcapsules on Earth and are now performing activities leading to FDA approval for use in cancer treatment.  

In addition, the ISS National Laboratory managed by the Center for the Advancement of Science in Space (CASIS) has also sponsored cancer-related investigations.  An example of that is an investigation conducted by the commercial company Eli Lilly that seeks to crystallize a human membrane protein involved in several types of cancer together with a compound that could serve as a drug to treat those cancers. 

“So many things change in 3-D, it’s mind-blowing – when you look at the function of the cell, how they present their proteins, how they activate genes, how they interact with other cells,” said Jeanne Becker, Ph.D., a cell biologist at Nano3D Biosciences in Houston and principal investigator for a study called Cellular Biotechnology Operations Support Systems: Evaluation of Ovarian Tumor Cell Growth and Gene Expression, also known as the CBOSS-1-Ovarian study. “The variable that you are most looking at here is gravity, and you can’t really take away gravity on Earth. You have to go where gravity is reduced.“ 

Crunching Big Data Using Space Knowledge

Our Jet Propulsion Laboratory often deals with measurements from a variety of sensors – say, cameras and mass spectrometers that are on our spacecraft. Both can be used to study a star, planet or similar target object. But it takes special software to recognize that readings from very different instruments relate to one another.

There’s a similar problem in cancer research, where readings from different biomedical tests or instruments require correlation with one another. For that to happen, data have to be standardized, and algorithms must be “taught” to know what they’re looking for.

Because space exploration and cancer research share a similar challenge in that they both must analyze large datasets to find meaning, JPL and the National Cancer Institute renewed their research partnership to continue developing methods in data science that originated in space exploration and are now supporting new cancer discoveries.

JPL’s methods are leading to the development of a single, searchable network of cancer data that researcher can work into techniques for the early diagnosis of cancer or cancer risk. In the time they’ve worked together, the two organizations’ efforts have led to the discovery of six new Food and Drug Administration-approved cancer biomarkers. These agency-approved biomarkers have been used in more than 1 million patient diagnostic tests worldwide.