Secretagentpeptidebond - Mostly Harmless.

This week in “TBDMSCl crystals”

Purification of the “bad blood” from yesterday. 6 hrs later, the column is done and clean, and I’m in bed with Netflix and pizza after 2 looooong days in a row. Thank goodness!

hey, your blog is super great and you seem like a beautiful human being. i find you to be super inspiring! i know you get a lot of these questions, but is it okay to punch boys who tell me that i "can't can't be an engineer because I'm a girl"?

Not that I’m advocating violence, but if hypothetically you were to punch a shitty dude for being sexist, you should aim for the solar plexus or the stomach, not the face, because you’re less likely to hurt your hand and you’ll do more damage. Hypothetically of course. 

Sooooo satisfying!

My friend just told me that her PI was disappointed when one of her PhD students took a week off in the summer last year…

I just knew that my inherent mistrust of AI would save me someday

This robot led people to their doom — and they still followed it

Researchers from Georgia Tech, backed by money from the Air Force, ran a test to see if people trying to escape from a high-rise building would trust a robot to lead them. Overwhelmingly, the sheeple followed the little droid to their simulated deaths. In the video, the researchers theorize why people obliged.

Follow @the-future-now

Copper essential for burning fat, researchers find             

Though small amounts of copper are essential to health - oysters, liver, beans and nuts are good sources - copper’s role in metabolism has been unclear: Some studies found that it boosted fat burning, others that it depressed it.

University of California, Berkeley, Lawrence Berkeley National Laboratory and Howard Hughes Medical Institute researchers have now clarified the critical role that copper plays in nutrition: It helps move fat out of fat cells - called adipocytes - and into the blood stream for use as energy.

Without enough copper, fat builds up in fat cells without being utilized, said Christopher Chang, the Class of 1942 Chair and a professor of chemistry and of molecular and cell biology at UC Berkeley.

“Unlike other studies that link copper levels both to increased or decreased fat metabolism, our study shows definitively how it works - it’s a signal that turns on fat cells,” said Chang, who also is a faculty scientist at Berkeley Lab and a Howard Hughes Medical Institute investigator. “If we could find a way to burn fat more efficiently, this could be a big contribution to dealing with obesity and diabetes.”

The new study appeared online this week, and will be published in the July print issue of the journal Nature Chemical Biology.

“Copper regulates cyclic-AMP-dependent lipolysis” by Lakshmi Krishnamoorthy, Joseph A Cotruvo Jr, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S Pendyala, Shang Jia, Allegra T Aron, Cheri M Ackerman, Mark N Vander Wal, Timothy Guan, Lukas P Smaga, Samouil L Farhi, Elizabeth J New, Svetlana Lutsenko and Christopher J Chang in Nature Chemical Biology. Published online June 6 2016 doi:10.1038/nchembio.2098

Caption: The crystal structure of the cAMP-degrading enzyme phosphodiesterase PDE3B, showing two magnesium atoms (green) in the active site. Copper binds one of the amino acid residues in the pink loop at the left, blocking the activity of the enzyme. Credit: Lakshmipriya Krishnamoorthy and Joseph Cotruvo Jr., UC Berkeley

Always Have Ice

[Like Kurt Gödel and Alan Turing] I am also besotted with mathematics… I am absolutely struck with the power of mathematics, and that’s why I’m a theoretical physicist. If I want to answer questions, I love that we can all share the mathematical answers. It’s not about me trying to convince you of what I believe or of my perspective. We can all agree that one plus one is two, and we can all make calculations that come out to be the same, whether you’re from India or Pakistan or, you know, Oklahoma.

Magnificent On Being interview with cosmologist and theoretical physicist Janna Levin, who studies black holes, is the author of a bewitching novel about Kurt Gödel and Alan Turing, and has written beautifully about the relationship between genius and madness. (via explore-blog)

Also, while this is on my mind. In my master’s-level food toxicology class today we discussed various genetically modified crops and watched part of a documentary about them, and as someone with a food science degree I would like to be clear about the following:

The only health risk that has been shown to us throughout twenty plus years of having genetically modified crops as part of the food system is that there is a possibility of introducing proteins that could cause allergic reactions. New strains are required to be tested for this, of course, but that is a practical risk that needs to be closely monitored.

The objection to GM in general should be the patenting of genes and other legal matters; there are a number of crops that have been saved from blight and overall extinction via modification in the past two decades, and much like putting up inaccessibly expensive paywalls to scientific journals, patenting of genes within crops limits our ability within universities, small research companies, etc to make significant breakthroughs to further the scientific progress of humanity. 

Furthermore. People think of organic crops as the environmentally-friendly option. If you believe this, please pay attention to what I’m about to say. Current regulations dictate that to have a crop classified as organic the land on which the crop is grown has to have been pesticide-free for a significant amount of time. There is no interim label available to farmers. So what do they do? Do they use no pesticides and take the losses from disease and insects for a decade, waiting for a time in which they are allowed to reclassify their crops in such a way that they can sell them for more money?

Of course they don’t. It isn’t practical. You can say what you like about how the system is structured; I’d personally like to see an interim classification come into play. But what farmers actually do, and states like Montana are feeling the full effects of this–they clear-cut forests and plant their organic crops on entirely new land.

You want to tell me that clear-cutting forests is environmentally friendly? It’s not. Hell, for all that people make a big deal about saving the environment by limiting how much paper they use, paper production is done in a more sustainable manner (because the paper farms replant their trees in a regular cycle so as to not deplete their sources; they don’t just go out and cut down random trees). 

There are objections to be had in regards to GM crops on a legal basis. On a scientific one, there isn’t much. Call them frankenfoods all you want; look up what most commercially-sold produce truly looks like in the wild with no modification and you will learn very quickly that all foods have been modified in some way over the years through conventional breeding. We just think of that differently. 

Biotechnology is not the enemy. Pseudoscience tells us that this is the case. Pseudoscience also tells us that we should seek out natural supplements instead of medicine, and, well… that’s a rant for another day, but suffice to say it’s an even more dubious proposition.

Don’t buy into it.