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While a case can certainly be made for the mad scientist as an anti-intellectual caricature, I can’t help but feel that a lot of what goes into mad-science-oriented media only makes sense if you assume that the primary target audience is actual scientists. Like, this weirdo is performing wildly unethical human experimentation in an unhinged quest to conquer death and the principal objection their peers raise against those experiments is that their methods lack rigour? That’s a gag only a scientist would come up with.